CXCL8 and age-related macular degeneration: When these specific inflammatory markers were assessed at the systemic level, the serum IL-8 and IL-6 levels were found to be significantly elevated in the AMD patients (10.48 ± 1.79 pg/mL and 12.97 ± 1.46 pg/mL, respectively) compared to control subjects (6.07 ± 0.76 pg/mL and 8.76 ± 0.62 pg/mL, correspondingly) (Fig 1E and 1F).