Stewart et al. also showed that epileptiform activity at CA3-CA1 synapses induced by GABAAR inhibition is attenuated by acutely increasing O-GlcNAclyation, and that GluA2 is required to attenuate the epileptiform activity36, which highlights a beneficial effect of increasing O-GlcNAcylation levels to treat seizure disorders and epilepsy. Here, GRIA2 is linked to epilepsy.