However, there is a significant difference between the mean total LysoPC isoform levels in 2016 and 2017 (Mann–Whitney test, p = 0.0035) although the mean levels in either year are not different from uninfected control plasma and no other clinical parameters, including parasitemia, WBC, Age, Hb levels or temperature differed between the 2016 and 2017 patients in the cohorts (Supplementary Fig. 2a and b). The gene discussed is GSTM1; the disease is parasitic infectious disease.