Geldanamycin effectively disrupted the interaction of HSP90 with CD167a in the T24 model (Fig. 6f), and convincingly diminished ASMC-induced Stat3 tyrosine phosphorylation in a dose-dependent manner, both in T24 bladder cancer (Fig. 6h) and the human PDX models (Fig. 6i). Here, STAT3 is linked to urinary bladder carcinoma.