Subsequent detailed analysis also revealed a significant and positive correlation between COL1A1 and COL1A2 gene expression with increasing tumor staging [Fig. 1b, cohort I: COL1A1 p = 1E-9 and COL1A2 p = 7E-4, Ta/T1 (n = 103), T2 (n = 26), T3 (n = 13), T4 (n = 23); cohort II: COL1A1 p = 0.0036 and COL1A2 p = 4E-04, Ta/T1 (n = 15), T2 (n = 17), T3 (n = 42), T4 (n = 19); cohort III: COL1A1 p = 3.32E-11, and COL1A2p = 1.61E-09, Ta/T1 (n = 4), T2 (n = 120), T3 (n = 194), T4 (n = 58)]. The gene discussed is COL1A1; the disease is neoplasm.