To determine the relationship between circulating microRNAs and AngII-induced renal injury, we examined miR-103a-3p levels in human urine and blood samples from normotensive healthy controls (n = 18) and patients with hypertensive nephropathy (HN, n = 31), detected using a blood pressure threshold of >130/90 mm Hg and renal pathology (Supplementary Table 1). The gene discussed is AGT; the disease is hypertensive nephropathy.