Hence, our study taken together with these reports suggests that non-small cell lung cancer presents as 2 phenotypes, RASSF1Alow where RASSF1A is epigenetically or genetically silenced26,41, and RASSF1Ahigh where RASSF1A expression is maintained and even increased in response to hypoxic microenvironment. The gene discussed is RASSF1; the disease is non-small cell lung carcinoma.