We also analyzed gene expression profiles of HER2+ breast tumors from public data bases (www.kmplot.com) and found that high PKR mRNA levels are associated with increased relapse-free survival (RFS) and increased distant metastasis free survival (DMFS) of HER2+ breast tumor patients, who underwent neoadjuvant chemotherapies (Fig. 7a). The gene discussed is EIF2AK2; the disease is breast neoplasm.