FAS and metabolic dysfunction-associated steatohepatitis: These data indicate that db/db mice fed with an MCD diet for 11 weeks have the dysregulated lipid metabolism, leading to increased hepatic FFA, as occurs in NASH, and treatment with KT alleviated the abnormal lipid metabolism by decreasing the uptake (Cd36 and Pparγ) and synthesis of FFA (Pparγ, Fas, and Srebp1c) and by increasing the beta-oxidation.