The potential of these CD40-activated B cells have been tested and validated in vivo in models of Human papillomavirus 16 (HPV16) E6 and E7 expressing TC-1 tumor [94], B16-F10 melanoma, E.G7 lymphoma [95], 4T1 breast tumor metastasis [96], sarcoma [25] and in spontaneous non-Hodgkin’s lymphoma in dogs [97]. The gene discussed is CD40; the disease is neoplasm.