Ricciardi et al. showed that co-culture of B cells with the cancer cells MCF7 induces apoptosis of B cells and appearance of a Breg population (CD56+ CD24hi CD34hi) only when MCF7 underwent epithelial-to-mesenchymal transition (EMT), a process involved in cancer progression and metastasis and involving broad transcriptional and secretome changes [55]. The gene discussed is NCAM1; the disease is cancer.