For exosomes released by the highly metastatic A375 melanoma cell line and HEMa-LP normal melanocytes, 2D DIGE-MS analysis identified 11 differentially expressed proteins, including annexin A1, annexin A2, syntenin-1, and hyaluronan and proteoglycan link protein 1 (HAPLN1), all involved in angiogenesis, invasion, migration, and metastasis of melanoma cells [27]. The gene discussed is ANXA2; the disease is melanoma.