When previous CVD was replaced in the model by previous coronary heart disease, cerebrovascular disease, or PVD, it appeared that the relation between CTGF and previous CVD was most evident in PVD (β = 0.20, p < 0.001, 22.5% (11.9%–34.2%) increase in CTGF if previous PVD was present). Here, CCN2 is linked to cerebrovascular disorder.