Collectively, this has led to the suggestion that acne-associated phylogroups may have increased potential to induce acne via induction of Th1 and Th17 responses, and that lineages currently classified as non-acne-associated or neutral with regards to their presence on both acne and healthy subjects may also be associated with mainly Th1 responses, despite counterbalancing IL-10 induction, or Th17 responses. The gene discussed is IL10; the disease is acne.