Many of the genes exhibiting higher H3K27me2/3, which can span large chromatin regions, are cancer-associated and include cyclin-dependent kinase inhibitor 2A (CDKN2A) encoding the tumor suppressor p16/INK4A and cell cycle regulator Cyclin-dependent kinase 6 (CDK6) [66]. The gene discussed is CDKN2A; the disease is cancer.