The Becher lab developed another murine model of DIPG with H3.3 K27M, activated PDGFB, and knock-out of TP53, which showed downregulated p16/INK4A expression with increased levels of H3K27me3 at the p16/INK4A promoter. This evidence concerns the gene CDKN2A and diffuse intrinsic pontine glioma.