In contrast, western blotting and immunocytochemistry reports of enhanced KCC2 expression in specific locations of the hippocampi resected from patients with human temporal lobe epilepsy [98] indicate KCC2 expression may be differentially up or downregulated both by location in hippocampus and on neuronal structure (i.e.; soma vs. dendritic spines). Here, SLC12A5 is linked to temporal lobe epilepsy.