Recent studies from our laboratory and others also demonstrated that CHIT1 is dysregulated in lung diseases characterized by inflammation and remodeling such as bacterial infection, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis (Lee et al, 2012; Cho et al, 2015; James et al, 2016; Hong et al, 2018; Sharma et al, 2018). Here, CHIT1 is linked to chronic obstructive pulmonary disease.