TGFB1 and metabolic dysfunction-associated steatohepatitis: In this regard, it is reasonable to speculate that CHIT1 also could play an important role in the pathogenesis of other organ fibrosis including sarcoidosis and nonalcoholic steatohepatitis that showed dysregulated levels of both CHIT1 and TGF-β (Peverill et al, 2014; Casanova et al, 2015).