Given the widespread association of GLI1 with many human cancers including glioblastoma, basal cell carcinoma, lung cancer, GI cancers, prostate cancer [1], medulloblastoma [11,29,30] and rhabdomyosarcoma [31-33], it is important to understand key elements of the regulation of GLI1 expression. The gene discussed is GLI1; the disease is basal cell carcinoma.