Because inhibition of BRD4 binding by I-BET151 in mouse cells reduced GLI1 expression and is a candidate cancer therapy [28] we wished to determine the effect of I-BET151 on BRD4 and activating histone marks in human tumor cells with an intact SHH signal pathway but SHH autonomy to avoid potentially confounding effects of SHH. The gene discussed is SHH; the disease is cancer.