Furthermore, BayK8644 significantly enhanced the antitumoral effect of anti-PD-1 therapy in mice bearing 5555 melanoma (Figure 6O), whereas this effect was apparent in LL/2 lung cancer (Figures S8J and S8K) and MC38 colon cancer (Figures S8L and S8M) models, albeit not reaching statistical significance. Here, PDCD1 is linked to colonic neoplasm.