TMEM176B and neoplasm: Although TMEM176B is expressed by the three tumor cell lines studied (Figure S2E), immune cells from tumor-bearing Tmem176b−/− animals did not show enhanced in vivo cytotoxicity against WT cells compared with tumor-bearing Tmem176b+/+ mice (Figure S2F), suggesting that tumor-associated TMEM176B is not immunogenic in Tmem176b−/− hosts.