Moreover, in vitro re-stimulation of TDLN cells with ovalbumin (OVA) showed increased proportion of IL-17+ CD4+ T cells in Tmem176b−/− compared with WT mice (Figure S2K), and in vivo IL-17A blockade showed a clear trend toward suppression of the antitumor effect in tumor-bearing Tmem176b−/− mice (Figure S2L). The gene discussed is CD4; the disease is neoplasm.