CPA3 and osteoarthritis: To ascertain whether the reduction in osteoarthritis-related pathology in KitW-sh/W-sh and Cpa3-Cre;Mcl-1fl/fl mice was in fact due to the absence of mast cells, we engrafted bone marrow-derived mast cells into KitW-sh/W-sh and Cpa3-Cre;Mcl-1fl/fl mice to generate mast cell-sufficient mice.