CD8A and infection: We performed similar experiments (S2A Fig) using TCR beta-chain transgenic Mini cells (containing roughly 10% CD8 T cells specific for the M38316-323 epitope) for adoptive transfer, and observed a similar pattern: In female hosts, the rejection of male M38-specific CD8 T cells occurred two to three weeks post infection and the created "space" was not replenished by endogenous M38-specific CD8 T cells (S2B Fig, S2C Fig).