ICAM4 and Schnyder corneal dystrophy: Human RBCs express a large number of adhesion receptors on their membrane such as basal cell adhesion molecule/Lutheran (BCAM/Lu) and intercellular adhesion molecule-4 (ICAM-4), both of which are known to play a significant role in the genesis of vaso-occlusion in SCD [8, 14, 16–20].