The AR antagonist bicalutamide induces telomere DNA damage in a variety of prostate cancer cells that express different forms of AR [7, 8]: LNCaP cells that express mutant AR [8], LAPC4 cells that express wild-type AR [7], and 22Rv1 cells [15] that express both full-length AR (f-AR) and a constitutively active AR splice variant, AR-V7, that lacks the ligand-binding domain [8]. The gene discussed is AR; the disease is prostate cancer.