AR antagonist-induced telomere DNA damage in LNCaP prostate cancer cells appears to be mediated by telomere-associated AR, as AR-chromatin immunoprecipitate (AR-ChIP) contains telomeric DNA, isolated telomeric chromatin contains AR, and AR co-immunoprecipitates and colocalizes with shelterin proteins TIN2, TRF1 and TRF2 [6, 7]. Here, TINF2 is linked to Familial prostate cancer.