To determine whether decreased hepatic asprosin and increased AMPK levels modulate glucose-regulated signaling pathways, we examined the levels of GLUT4, PGC-1α, PGC-1β, FNDC5, and UCP3 in the liver of T1DM rats following 8 weeks of aerobic exercise training. The gene discussed is FNDC5; the disease is type 1 diabetes mellitus.