Using a genetic model of intestinal epithelial cell (IEC)-restricted constitutive Wnt-activation, which comprises the most common event in the initiation of colon cancer, it was demonstrated that NF-κB modulates Wnt signaling and that IEC-specific ablation of RelA/p65 retards crypt stem cell expansion [141]. The gene discussed is NFKB1; the disease is colonic neoplasm.