Moreover, local therapy offers certain advantages over systemic therapies, such as a delivery of higher concentrations of the drug into the tumor, minimal systemic side effects, no required tumor antigen identification, in situ vaccination by tumor authentic antigens, no pretreatment biopsy, no major histocompatibility complex (MHC) restriction, polyclonal T and B cell stimulation, and low cost [4,47]. This evidence concerns the gene HLA-C and neoplasm.