In line with this are findings from mice, where a choline-deficient L-amino acid-deficient- or a methionine/choline-deficient diet-dependent NAFLD was ameliorated due to hepatocyte-specific deletion of HIF-2α and by concomitant decreased macrophage M1 polarizing histidine-rich glycoprotein (HRGP) expression [129], which links HIF-2α to inflammation and NASH. This evidence concerns the gene HRG and metabolic dysfunction-associated steatotic liver disease.