Many genomic regulatory regions were revealed for the melanoma states from joint transcriptome and methylome profiling, and master regulators were identified in SOX10/MITF (SOX-10 is a marker for melanocytic differentiation, and its dysfunction impairs MITF, the Microphthalmia transcription factor expression, as well as melanocytic development and survival), and AP-1/TEAD (together, they critically regulate transcriptional and functional mechanisms in cancer cells, particularly invasion and resistance [86]). Here, JUN is linked to melanoma.