On the one hand, elevated CTRP1 levels lowers blood glucose levels without altering insulin or adiponectin levels [2,3], and on the other hand, high CTRP1 concentrations protect from diet-induced obesity and insulin-resistance, while CTRP1 knockout mice developed insulin resistance and hepatic steatosis [6,11]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.