A recent meta-analysis reports a reduction in the plasma inflammatory biomarkers, C-reactive protein, IL-6, and TNF-α, after CoQ10 supplementation (60 to 500 mg/day, formulations described as CoQ10 or ubiquinol), for 1 week to 4 months in different inflammatory disorders (cardio and cerebral vascular disease, multiple sclerosis, obesity, renal failure, rheumatoid arthritis, diabetes, and fatty liver disease). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.