SIRT1 and Insulin resistance: These findings of increased cAMP, SIRT1 (sirtuin 1) expression, and PGC-1α in reducing parameters of oxidative stress and increasing mitochondrial function were also confirmed in other experiments with ubiquinol supplementation in senescence-accelerated mice, with added benefits in obesity, insulin resistance, and metabolic syndrome, (hypothesized mechanism in Figure 4 [106]).