In CRC, the ectopic expression of c-Myc by retrovirus rescues the reduction of organoid-forming efficiency and proliferation in Proliferating Cell Nuclear Antigen (PCNA)-associated factor (PAF) KO Lgr5+ organoids, suggesting that the PAF-transactivated c-Myc (PAF-Myc axis) is required for expansion of the intestinal stem and the progenitor cells during intestinal regeneration and tumorigenesis [110]. This evidence concerns the gene PCLAF and colorectal carcinoma.