By studying a dataset of testicular cancer patients, we minimized the influence of gender, older age, comorbidities and long-term use of medications that could have affected the renin-angiotensin systems (e.g., angiotensin converting enzyme inhibitors and angiotensin receptor blockers) and nephrotoxic compounds (e.g., non-steroidal anti-inflammatory drugs). The gene discussed is REN; the disease is testicular cancer.