ERCC1 and acute kidney injury: Furthermore, we found that variant genotypes were protective against cisplatin nephrotoxicity when applying the CTCAE-AKI definition of nephrotoxicity: heterozygous carriers of the ERCC1 rs3212986 had an ORadj of 0.24 (95% CI: 0.08–0.70) while the homozygous variant had an ORadj of 0.43 (95% CI: 0.07–2.47; p = 0.341).