As other NR2E3 mutations that have been found in autosomal recessive IRDs, such as enhanced S-cone syndrome (ESCS, MIM 268100), have a loss-of-function effect, we hypothesized that the c.166G>A allele could function as a therapeutic target for selective suppression [35] (Figure 1). Here, NR2E3 is linked to Goldmann-Favre syndrome.