KCNJ10 and aceruloplasminemia: Nevertheless, the observed pathological changes showed similarities to other spinocerebellar ataxias, such as KCNJ10-related spongy degeneration with cerebellar ataxia (SDCA1) in Belgian Shepherd Dogs (OMIA 002089) [9], and the vacuolization with marked astrogliosis indicated intramyelinic edema, which was compatible with an ion channel defect.