LRP1 and Alzheimer disease: In both AD-derived human vSMCs and in AD mouse models, it was reported that the transcription factors serum response factor (SRF) and myocardin (MYOCD) are significantly upregulated within vSMCs [272], resulting in Aβ clearance deficits through the expression of sterol regulatory element binding protein-2 (SREBP2) and the subsequent downregulation of LRP1 [273].