Furthermore, when a single-nucleotide polymorphism in the PICALM gene known to be protective in AD was expressed in induced pluripotent stem cell (iPSC)-derived endothelial cells, it was found that the protective allele resulted in 72–78% higher expression of PICALM mRNA and protein and 120% higher clearance of Aβ than the AD-associated allele. The gene discussed is PICALM; the disease is Alzheimer disease.