Neutrophil trafficking across the BBB is increased in 5xFAD mice and 3xTg-AD mice and this appears to be related to the vascular upregulation of adhesion molecules like vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), E-selectin and P-selectin [216]. Here, VCAM1 is linked to Alzheimer disease.