NFKB1 and colorectal cancer: The TLR5 rs5744174 C/C genotype was also associated with increased risk for some cancers, including GC [26] and a lower survival in colorectal cancer by influencing cytokine response to intestinal bacteria [26] However, NF-κB paradoxically may also be involved in autoimmune suppression, by promoting the development and the immunosuppressive function of regulatory T cells, which are also crucial for central and peripheral tolerance, although this factor alone was not enough [43].