SPP1 and neuromuscular disease caused by qualitative or quantitative defects of dystrophin: Furthermore, they add one more layer of complexity to the role of osteopontin in muscle remodeling in dystrophin deficiency—it has to be reminded that muscle hypertrophy may be beneficial in dystrophic patients and animals, insofar as it increases strength, but it may be detrimental when it exacerbates agonist-antagonist imbalance and joint contractures.