ERBB2 and breast cancer: Another study identified a tumor suppressive role of miR-1296-5p in HER2-positive breast cancer cells; increased miR-1296-5p levels reduced its target protein level and mTORC1/S6 activation; thus, miR-1296-5p is able to block cellular proliferation of HER2-positive breast cancer cells and increase their sensitivity to cisplatin and 5-fluorouracil-induced apoptosis [174].