Expressions of phospho-protein kinase R-like endoplasmic reticulum kinase (p-PERK), p-eIF2α, ATF4, p-IRE1α, phospho-c-Jun N-terminal kinase (p-JNK), and CHOP were significantly higher in CKD-MSCs compared to their expression in healthy-MSCs. Here, EIF2AK3 is linked to chronic kidney disease.