On the other hand, tyrosine phosphorylation of Grb7 can also be detected when Grb7 binds to HS-1-associated protein X-1 (HAX-1), a cytoskeletal-associated protein that is overexpressed in metastatic cancers [40], suggesting the potential role of tyrosine phosphorylation of Grb7 in cancer development. Here, GRB7 is linked to metastatic malignant neoplasm.