CFTR and cystic fibrosis: In CF, this disturbed microbiota, usually named “dysbiosis”, stems from multiple factors including hydro electrolytic disruptions of the intestinal secretions, slower gastrointestinal transit time [12], drug uses, impaired innate immunity in the gut [13,14], and hypercaloric diet [15,16], and appears to be correlated with the severity of the CFTR mutations [11].