PRNP and infection: During the disease pathogenesis, the PrPSc seeds, either acquired through infection or elicited from spontaneous conversion of wild-type or mutated PrPC, template the conversion of host-PrPC into PrPSc by an autocatalytic manner, resulting in the deposition of pathogenic PrPSc assemblies in the brain and sometimes in extraneural tissues, such as the lymphoid tissue [2].