IGF1 and chronic kidney disease: For expansion and verification of the knowledge in the area of miRNA's role in adaptation processes of chronic kidney disease patients, we will analyze the effect of IRT on miRNAs involved in calcium metabolism, on miR206 involved in Insulin-like growth factor 1 (IGF-1) signalling pathway and on miR23-a involved in E3 ubiquitin-protein ligase (Tripartite motif containing 63 – TRIM63) signalling pathway.