NPM1 and acute promyelocytic leukemia: The complete remission rate can achieve 90% and nearly 70% of them are potentially cured.[3–5] Seven types of atypical APL have been found, including PLZF-RARα (promyelocytic leukemia zinc finger), NuMA-RARα(nuclear mitotic apparatus protein),NPM-RARα(nucleophosmin), F1P1L1/-RARα(FIP1-like 1), BCOR-RARα(BCL6 corepressor), STAT5b-RARα(Signal transducer and activator of transcription 5b), and PRKAR1A-RARα(protein kinase A regulatory subunit type 1A).