Yixinshu Capsule (YXS), a ShengMai-San-derived TCM formula, is widely used in Asia for the treatment of cardiovascular diseases as a conventional drug,[13,14] which has a potent effect on maintaining cardiac function by reducing oxidative stress injury and mitochondrial-mediated apoptosis.[12,13] And a new research[15] had demonstrated that Yixinshu capsule has distinctive treatment features against heart failure, which maybe particularly suitable for heart failure patients with exaltation of FABP3 and CKAP5. This evidence concerns the gene CKAP5 and heart failure.