CKAP5 and cardiovascular disorder: Yixinshu Capsule (YXS), a ShengMai-San-derived TCM formula, is widely used in Asia for the treatment of cardiovascular diseases as a conventional drug,[13,14] which has a potent effect on maintaining cardiac function by reducing oxidative stress injury and mitochondrial-mediated apoptosis.[12,13] And a new research[15] had demonstrated that Yixinshu capsule has distinctive treatment features against heart failure, which maybe particularly suitable for heart failure patients with exaltation of FABP3 and CKAP5.