In consonance to previous report, main postulates of water flux disturbance in scedosporiosis are (i) physical disruption due to space-occupying lesion from abscess formation resulting in high cerebral pressure and subsequent to neuronal ischemia and (ii) biochemical signal, e.g., proinflammatory cytokines especially TNF-α leading to permeability alteration. The gene discussed is TNF; the disease is abscess.