As measures of the pro-survival signal of the LRP1 agonist, pAkt levels increased together with a significant reduction in in proapoptotic to antiapoptotic Bac/Bcl2 ratio and caspase-3 expression in the myocardial tissue at 24 h from acute ischemia, suggesting that LRP1 rapidly activates the RISK pathway upon reperfusion (20) (Figure 3B). The gene discussed is LRP1; the disease is ischemia.