As LRP1 is highly expressed in a variety of cell types in the CNS including glial cells, neurons and vascular cells, and serves as a major receptor for a wide range of molecules such as ApoE and amyloid β (Aβ), which play critical roles in AD, numerous studies addressed LRP1 endocytic/signaling functions for novel diagnostic and therapeutic strategies (54). The gene discussed is LRP1; the disease is Alzheimer disease.