Indeed, Soler-Cardona et al. reported that CXCL5-overexpressing melanomas had significantly increased lymph node metastases of melanoma (15) caused by the recruitment of immunosuppressive PD-L1-expressing neutrophils, leading to interference with systemic activation of the anti-tumor immune system using poly (I: C) (14). The gene discussed is CXCL5; the disease is neoplasm.