Since serum sCD163 and CXCL5 are, at least in part, derived from CD163+ TAMs that are activated by periostin (24, 26), and chemokine profiles from TAMs are determined by the stimulation of stromal factors (27), spontaneously produced TAM-related factors could be detected in serum from melanoma patients (17, 25, 27). This evidence concerns the gene CD163 and melanoma.