For instance, when tumors developed in mouse brain in our orthotopic mouse model, similar features of tumor infiltration, i.e., small but highly invasive tumors have been observed in CD90 expressing (Avril et al., 2017a) and IRE1 defective (Dominant Negative, DN; Auf et al., 2010) U87 cells. The gene discussed is ERN1; the disease is neoplasm.