Recently, we identified the complex formed by NF-κB-regulated antiapoptotic factor, GADD45β, and the c-Jun N-terminal kinase (JNK)-activating kinase, MKK7, as an essential, cancer-selective survival module downstream of NF-κB and novel therapeutic target in MM [11,[18], [19], [20]]. The gene discussed is MAP2K7; the disease is Miyoshi myopathy.