In this report, we describe a case of laryngeal cryptococcosis and his plausible risk factors of laryngeal cryptococcosis including inhaled corticosteroid use, Mycobacterium avium-intracellulare (MAI) infection, and MBL deficiency, and discuss key points of laryngeal cryptococcosis from previous case reports. Here, MBL2 is linked to hyperinsulinemic hypoglycemia, familial, 4.