These proteins promote cell invasion by influencing ERK1/2 and Glycogen Synthase Kinase 3α/β (GSK-3α/β) signaling [10]; Src, ERK1/2, and AMP-activated protein kinase 1 (AMPK1) signaling [11]; and alpha-actinin 4 (ACTN4) and p27 signaling [12] in pancreatic cancer, respectively. Here, ACTN4 is linked to familial pancreatic carcinoma.